IRAK1 and cancer: Notably, the KEGG and GO enrichment analysis of IRAK1 correlated genes suggested that IRAK1 was related to immune pathways, including PD-L1 and PD-1 checkpoint pathway in cancer, Toll-like receptor signaling pathway, interleukin-1 receptor binding, and innate immune response-activating signal transduction (Figures 5D,E).