IRAK1 and neoplasm: Although IRAK1 has been proved to play an important role in tumor malignant proliferation, metastasis and drug resistance acquisition in a variety of tumors, the clinical usefulness of IRAK1 inhibitor has not been clarified in clinical studies (Jain, Kaczanowska, and Davila 2014; Wee et al., 2015; Meng et al., 2020).