Although studies have shown that tumor mutation burden (TMB), tumor microsatellite instability (MSI), tumor copy-number alterations (CAN) and PD-L1 expression level can be used to predict the prognosis of ICIs (Dudnik et al., 2018; Davis and Patel 2019; Samstein et al., 2019; Lu et al., 2020). This evidence concerns the gene CD274 and neoplasm.