TNFSF10 and melanoma: For example, the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is differentially expressed in a variety of malignant tumors, such as lymphoma, bladder cancer, melanoma, and esophageal cancer, is capable of exerting a selective apoptotic effect (Fulda 2014; Alexiou et al., 2015).