Mutations in the oncogene PTEN (phosphatase and tensin homolog deleted on chromosome ten) are detected in hematological tumors, brain gliomas, osteosarcoma and many other tumors and can be the target for microRNA-21–5p to reduce the migration of keloid fibroblasts and govern autophagy (Worby and Dixon 2014; Chen et al., 2018; Yan et al., 2020). Here, PTEN is linked to osteosarcoma.