evaluated the modulatory effect of resveratrol, both as a monotherapy and in combination with 5-FU in 3D colon cancer cell models (HCT116) and their isogenic clones resistant to 5-FU (HCT116R), in the presence of an inflammatory microenvironment mediated by the addition of the proinflammatory cytokines TNF-β (Tumor Necrosis Factor Beta) and TNF-α (Tumor Necrosis Factor Alfa). The gene discussed is LTA; the disease is colonic neoplasm.