ERCC4 and neoplasm: One such study found that the small molecules NSC143099 and NSC16168 can inhibit the activity of the ERCC1-XPF heterodimer, an endonuclease that is essential in multiple DNA repair pathways in mammal cells, which results in the potentiation of cytotoxicity induced by CDDP in tumor cells and the inhibition of tumor growth in animal models [68].