The fact that atherosclerosis is not a prominent feature of HH in spite of the existence of excess iron accumulation in multiple tissues very strongly supports that body iron overload, if not accompanied by the “increased iron content in the aortic tissues,” is not a significant factor in atherosclerosis, but the role of iron in ApoE deficiency-induced atherosclerosis cannot be completely denied because iron contents are increased in the aortic tissues of ApoE–/– mice. This evidence concerns the gene APOE and hyperinsulinemic hypoglycemia, familial, 4.