Adjusting cTnT cut-off retained good performance at detecting acute myocardial infarction in people with CKD (cTnT > 350 ng/L (standard cut-off > 14 ng/L) for eGFR < 15 ml/min/1.73 m2: sensitivity 95%, specificity 97%; cTnT cut-off > 43.2 ng/L for eGFR < 60 ml/min/1.73 m2: sensitivity 92%, specificity: 88%) (63, 64). The gene discussed is TNNT2; the disease is myocardial infarction.