In people undergoing cardiac surgery, urinary IL-18 also modestly predicted AKI (AUC-ROC 0.61 at 4 h post-surgery, 0.75 at 12 h, and 0.73 at 24 h), (56) which was superior to clinical models using eGFR, (42) and was associated with a modest 1.2-fold increased risk of long-term mortality (52). Here, IL18 is linked to acute kidney injury.