In acute HF, while NT-proBNP was superior to galectin-3 for diagnosis, galectin-3 may be superior to NT-proBNP at predicting 60-day mortality (AUC-ROC 0.74 vs. 0.67, p = 0.05) and was associated with a 14-fold increased risk of all-cause death or HF hospitalization in multivariate analysis (30). The gene discussed is NPPB; the disease is hydrops fetalis.