The level of ROS, the expression of NOX2 and NOX4 in the LA, and the concentration of H2O2 and MDA in serum were remarkably increased in the MDD rats versus the CTL rats (p < 0.05, Figures 8B–E,G,I), and the activity of SOD and the ratio of GSH/GSSG in serum were clearly reduced in the MDD rats (p < 0.05, Figures 8F,H). The gene discussed is SOD1; the disease is major depressive disorder.