SIRT3 and Alzheimer disease: SIRT3 activation alleviates Aβ toxicity and repairs mitochondrial bioenergetics and maintains mitophagic activity and cognitive function in AD (Meng et al., 2019; Li et al., 2020; Yin et al., 2020; Yu et al., 2020; Zhang et al., 2020; Tyagi et al., 2021).