SIRT1 is a NAD-dependent deacetylase that is involved in the regulation of autophagy and mitophagy (Lee et al., 2008; Salminen and Kaarniranta, 2009; Jang et al., 2012; Ou et al., 2014) and displays neuroprotective implications in AD (Julien et al., 2009; Gomes et al., 2018). This evidence concerns the gene SIRT1 and Alzheimer disease.