FOXO3a served as a transcription factor highly represented in the brain and a new target of AD diagnosis (Pradhan et al., 2020), that maintains cellular homeostasis against stresses for neuronal protection, and regulates the transcriptional activity of autophagy (BECN1, ATG12, PIK3C3) and mitophagic genes (BNIP3 and PINK1) (Greer and Brunet, 2005; Murtaza et al., 2017; Cheng, 2019). The gene discussed is FOXO3; the disease is Alzheimer disease.