Compared to ApoE3, ApoE4 inhibits DNM1L transcription and attenuates DRP1 expression in astrocyte cell lines (Schmukler et al., 2020), primary astrocytes, and hippocampus from ApoE-TR mice (Yin et al., 2020), and the ostmortem brain specimens from APOE ε4 carriers and patients with AD carrying APOE ε4/4 (Simonovitch et al., 2019; Yin et al., 2020). This evidence concerns the gene DNM1L and Alzheimer disease.