APOE and Alzheimer disease: Incidentally, the VDAC1-Aβ and VDAC1-Tau interaction is confirmed by double-labeling analysis and co-IP in the brains of AD subjects and several AD model mice (Manczak and Reddy, 2012b), while it is well known that ApoE4 mediates Aβ aggregation and Tau hyperphosphorylation (Ellis et al., 1996; Brecht et al., 2004).