APOE and Alzheimer disease: Many issues remain ambiguous and seem appealling for further investigations, however, both the functional and mechanistic multiformity of ApoE4 effects of mitophagy have emerged and been extensively enlightened in AD pathogenesis (Chen et al., 2011; Palikaras et al., 2017; Simonovitch et al., 2019; Schmukler et al., 2020; Sohn et al., 2021; Eran and Ronit, 2022).