ApoE has been extensively studied in multiple fields and displays new findings, such as the interaction of ApoE4-TFEB promoter (Parcon et al., 2018), ApoE4-SIRT1 promoter (Theendakara et al., 2016; Lima et al., 2020), and particularly ApoE-VADC (Chen et al., 2020) in myocardial cells, which deserves extending to neuronal researches, particularly mitophagy in AD. This evidence concerns the gene SIRT1 and Alzheimer disease.