APOE and Alzheimer disease: Although discrepant interaction between ApoE3 and ApoE4 could not be found, the finding enlighten the researchers to broadly examine the ApoE-VDAC interaction in neuronal models, including cell lines of neurons or glia, primary neuronal cells, and brain tissues from APOE-TR mice or AD model mice, even the APOE ε4 carriers and AD subjects, in order to explore whether the interaction exists in the neuronal system, whether there is a differential interaction between ApoE3 and ApoE4, and whether it is associated with AD pathogenesis.