Impaired mitochondrial dynamics is widely established in AD model mice and cells, as well as AD individuals (Manczak et al., 2011; Reddy et al., 2011, 2018; Manczak and Reddy, 2012a; Zhu et al., 2013; Kandimalla et al., 2021), as determined by the lower expression of mitochondrial fission genes (DRP1 and FIS1) and higher phosphorylation level of dynamin-related protein1 (DRP1), leading to reductive mitochondria fragmentation and neuronal energy dysfunction (Reddy et al., 2011; Manczak and Reddy, 2012a; Misrani et al., 2021; Wang et al., 2021a; Dhapola et al., 2022). Here, FIS1 is linked to Alzheimer disease.