MAPT and Alzheimer disease: Alzheimer's disease (AD) is the most common and well-known form of dementia and features age-related and progressive recognition impairment, memory loss, and learning failure, accompanied by encephalatrophy, and extracellular amyloid-β (Aβ) plaques, intracellular tangles of hyperphosphorylated Tau (Mahaman et al., 2022).