DNM1L and Cognitive impairment: Taken together, these findings suggest that ApoE4 disrupts mitochondrial fission by the inhibition of DRP1 transcription and expression (Schmukler et al., 2020), DRP-Aβ interaction (Manczak et al., 2016), DRP1-Tau interaction (Kandimalla et al., 2016), and the downregulation of its regulators SIRT1 level (Theendakara et al., 2013), ultimately resulting in dysregulated mitochondrial dynamics, consequently probably triggering irreversible and progressive neuronal damage and cognitive impairment (Manczak and Reddy, 2012a).