The levels of PINK1 and Parkin, as well as the related factors, are usually remarkably increased in vivo and in vitro models of AD and patients with AD (Mise et al., 2017; Ochi et al., 2020; Goudarzi et al., 2021), indicating various mitochondrial disturbances or dysfunctional mitophagy. Here, PRKN is linked to Alzheimer disease.