Incidentally, additional studies indicate that decreased DRP1 promotes cognitive performance and improves mitophagy and dendritic spines in tau-transgenic mouse model and APP/PS1 mice (Kandimalla et al., 2021; Misrani et al., 2021; Song et al., 2021), in which DRP1 is overactivated under abnormal conditions; and consistently, various DRP1 inhibitors promote fusion and improve cognition in AD (Dhapola et al., 2022). This evidence concerns the gene MAPT and Alzheimer disease.