CD274 and neoplasm: Additionally, based on the literature and our observation of the T and B population analysis, we assumed that the anti-PD-L1-scFv could also act on Breg, reducing the PD-1 positive Breg population at the tumor site and therefore restoring an anti-tumoral response mediated by the CD8+ T-cell population that increased in mice treated with Ad5Δ24-anti-PD-L1-scFv (39).