CD274 and neoplasm: In support of the hypothesis that reduction in tumor growth was due to increased antitumoral immune response, we observed an increment in the CD8+ T-cell population in the tumors of mice treated with Ad5Δ24 anti-PD-L1-scFv, suggesting that the combination of OV action and PD-L1 inhibition is beneficial for the recruitment and activation of cytotoxic T cells.