NAGPA and cancer: The result showed a negative correlation between FAM107A expression and TMB existed in most cancers including BLCA (P = 0.018), BRCA (P = 0.02), HNSC (P = 0.044), KIRC (P= 0.0043), LGG (Brain Lower Grade Glioma) (P= 0.0013), LIHC (P=0.0028), LUAD (P= 1.5e-07), LUSC (P= 0.0028), PAAD (P= 6e-08), PRAD (P= 5.3e-27), READ (P= 0.0073), SKCM (P= 0.014), STAD (P= 5.7e-15), THCA (P= 0.007) and UCE C (P= 0.00021).