Binding and transcriptional activation of VDR by 1,25(OH)2D regulate multiple pathways [including VDR-, peroxisome proliferator-activated receptor (PPAR)-, p53-, Wnt/β- (The term Wnt results from the fusion of the name of the Drosophila segment polarity gene termed wingless and the name of the vertebrate homolog, integrated or int-1), catenin-, and mitogen-activated protein kinase (MAPK)- mediated signaling] and functions that are implicated in carcinogenesis, cancer progression, metastatic potential, and immunosurveillance (12). Here, VDR is linked to cancer.