When potentially interfering factors, including location of metastases (e.g., in liver or kidneys, representing important organs for vitamin D metabolism), sex, age, history of other malignancies, diabetes mellitus, hyperlipidemia, hypercholesterinemia, stroke, coronary heart disease, heart insufficiency, heart rhythm disorders, hypertension, kidney, thyroid or liver disease, asthma bronchiale, ethanol and nicotine abuse, were assessed to adjust Cox regression modeling, mutations in BRAF, n-ras, and c-kit genes were identified, and Cox regression model was adjusted using these variables. The gene discussed is NRAS; the disease is Hypertension.