GSDME and cancer: Among them, 10 genes (BAK, BAX, CASP8, CHMP2A, CHMP4C, CSCY, GSDMA, GSDMB, TP53, and ZBP1) were upregulated, whereas 15 genes (CASP1, CHMP2B, CHMP3, CHMP7, ELANE, GSDMD, GSDME, HMGB1, IL18, ILα, ILβ, IRF2, NLRP1, NLRP9, and TP63) were downregulated in the cancer tissues.