We demonstrated that unlike UCK2 wild type, overexpression of catalytic dead UCK2 mutant (UCK2D62A) failed to promote HCC cell proliferation but still enhanced HCC metastasis, suggesting that UCK2 not only could promote HCC cell proliferation in a catalytic dependent manner but also could facilitate HCC metastasis in a catalytic independent manner (27). Here, UCK2 is linked to hepatocellular carcinoma.