The following genes were enriched with mutations compared to primary PCa: PRAD; AR, TP53, MYC, ZMYM3, PTEN, PTPRD, ZFP36L2, ADAM15, MARCOD2, BRIP1, APC, KMT2C, CCAR2, NKX3-1, C8orf58, and RYBP. Somatic alterations influencing the expression or function of AR have been reported as one of the main driving forces of castration resistance. Here, NKX3-1 is linked to posterior cortical atrophy.