Within primary PCa, driver-gene analysis revealed enrichment or recurrence of mutations or copy-number alterations within SPOP, FOXA1, IDH1, TP53, PTEN, PIK3CA, BRAF, CTNNB1, HRAS, MED12, ATM, CDKN1B, RB1, NKX3-1, AKT1, ZMYM3, KMT2C, KMT2D, ZNF770, CHD1, BRCA2, CDK12 as reported by The Cancer Genome Atlas (TCGA) consortium (66). This evidence concerns the gene PTEN and posterior cortical atrophy.