Given the well-known impact of genetic variants, including the single nucleotide polymorphisms (SNPs), on gene expression and activity of the encoded proteins which could influence disease susceptibility and phenotype (16, 17), the authors were inspired to explore for the first time the possible association of C1INH rs4926 gene variant and expression with neonatal lung disease risk and the clinical features in an Egyptian neonate cohort. The gene discussed is SERPING1; the disease is lung disorder.