Although this variant is classified as one of the C1INH benign variants (https://www.ncbi.nlm.nih.gov/clinvar/variation/254786/) and yielded conflicting results with age-related macular degeneration (35), interestingly, it showed a trend of association with susceptibility to staphylococcal aureus colonization of the nose (36). This evidence concerns the gene SERPING1 and age-related macular degeneration.