Available research and review have now established a possible role for MOG-immunoglobulin G (IgG) that was associated with a very heterogeneous age-dependent clinical presentation and multiple sclerosis (MS)-typical demyelination and oligodendrocyte pathology, defined as Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated disorders (MOGADs) (4, 5). Here, MOG is linked to multiple sclerosis.