MOG and acute disseminated encephalomyelitis: The main clinical phenotypes of MOG-IgG-associated demyelinating syndromes change with age, as ADEM-like presentations [ADEM, ADEM-optic neuritis (ON), and multiphasic ADEM] are more common in children <9 years old, and optical-spinal presentations (ON and myelitis) are more common in children aged >9 years and adults (8, 9).