PET studies in late-onset AD also showed that OSA is associated with greater amyloid [22,23] and tau [24] burden, as well as accelerated amyloid [25,26] and tau [26] deposition rates; although findings have been mixed [27] and differ based on the disease stage (e.g. cognitively normal vs MCI vs AD) and the sample (e.g. clinical vs sleep clinic vs community-based). Here, MAPT is linked to obstructive sleep apnea syndrome.