Hsieh et al. showed that OPN regulated the expression of glucose transporter 1 and glucose transporter 3 in osteosarcoma and enhanced glucose uptake in cells via the integrin αvβ3 (Le et al., 2003; Vergis et al., 2008; Raja et al., 2014; Ostheimer et al., 2017; Cao et al., 2019; Nishio et al., 2021). This evidence concerns the gene SPP1 and osteosarcoma.