There was no statistical significance between the TRALI group and non-TRALI group in terms of their gender, age, BMI, surgical history, perioperative blood transfusion volume, total infusion volume, HLA antibody I, mechanical ventilation, combined liver disease, IL-10, and the levels of TGF-β (P > 0.05); the comparison was statistically significant in the following aspects: the smoking history, HLA antibody II, pretransfusion shock, CD4 + CD25 + Treg between the two groups (P < 0.05), as shown in Table 1. The gene discussed is CD4; the disease is liver disorder.