Regarding the TB HDTs discussed in this review, several have been extensively tested in experimental models and also in clinical trials with positive results, such as those employing metformin, statins, NSAIDs and PDE-4 inhibitors for pulmonary TB as well as corticosteroids for TB-meningitis, and therefore, represent the most promising strategies so far. The gene discussed is PDE4A; the disease is pulmonary tuberculosis.