HMOX1 and cerebral malaria: Using an experimental model of infection with P. berghei ANKA, Pamplona et al., identified that the induction of HO-1 expression through the treatment with CoPPIX as well as the administration of CO, which is an end product of HO-1-mediated heme degradation, protects mice against severe lethal cerebral malaria, (Pamplona et al., 2007).