AdipoR2 is an adiponectin receptor that regulates lipid metabolism, fatty-acid oxidation, and adiponectin-induced biological functions (Kadowaki and Yamauchi, 2005; Ghadge et al., 2018) Therefore, adiponectin and AdipoR2 are potential therapeutic targets to combat NAFLD. This evidence concerns the gene ADIPOR2 and metabolic dysfunction-associated steatotic liver disease.