GSDMD and tauopathy: Although we aimed to investigate the effects of GSDMD on TBI-induced neurological deficits and neuropathological alterations in the early stage due to the high level of GSDMD at this time, the expression and cleavage of GSDMD is still higher at 7 days post TBI, so the long-term effects of GSDMD on TBI-induced brain damage including dementia and tauopathy should be investigated.