Metformin® is used to treat T2D patients to regulate the glucose levels and insulin resistance (34) it has been reported that because ABCG5/ABCG8 facilitate hepatobiliary transport of cholesterol, metformin can induce an increase in the heterodimer to facilitate the disposal of excess cholesterol through the hepatobiliary via (35). The gene discussed is ABCG8; the disease is type 2 diabetes mellitus.