CLCNKB and familial primary hypomagnesemia: In addition, the homozygous CLCNKB p.Arg76Ter variant has been reported in ClinVar (ID975076.2) to be associated with familial epilepsy, hypocalciuria, and proteinuria, although plasma magnesium and calcium concentrations were not reported, and hypomagnesemia and hypocalcemia, associated with GS and BS, are known metabolic causes of seizures [37].