Furthermore, she developed: type 2 diabetes mellitus; secondary hyperparathyroidism, osteoporosis, and vitamin D deficiency; glucose-6-phosphate dehydrogenase (G6PD) deficiency with hemolytic anemia from Pyridium (phenazopyridine hydrochloride); poor bladder control managed by a pacemaker; melanosis coli with colonic polyps; and depression. This evidence concerns the gene G6PD and major depressive disorder.