Moreover, the literature points out that berberine has inhibitory effects on four key enzymes related to the pathogenesis of Alzheimer s disease: monoamine oxidase B (MAO-B), acetylcholinesterase, monoamine oxidase A (MAO-A), and butyrylcholinesterase (Yuan et al., 2019). This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.