MAPT and early-onset autosomal dominant Alzheimer disease: Current typical histopathological changes in Alzheimer’s disease include Aβ plaques and tau tangles, the accumulation of these proteins leads to neuroinflammation and normal dysfunction, leading to neuronal death (Ameen and Michniak-Kohn, 2017; Bandiwadekar et al., 2021; Ye et al., 2021).