Current typical histopathological changes in Alzheimer’s disease include Aβ plaques and tau tangles, the accumulation of these proteins leads to neuroinflammation and normal dysfunction, leading to neuronal death (Ameen and Michniak-Kohn, 2017; Bandiwadekar et al., 2021; Ye et al., 2021). The gene discussed is MAPT; the disease is Alzheimer disease.