VIM and esophageal squamous cell carcinoma: To investigate whether DSE affects EMT process of ESCC cells, we examined the levels of Snail, E-cadherin and Vimentin proteins in KYSE450 and Eca109 cells administrated with DSE and found the treatment of DSE decreased the levels of Snail and Vimentin proteins and promoted the expression of E-cadherin protein (Figures 5E–H).