CFTR and cystic fibrosis: Non-clinical experiments with FEN have shown to normalize the aberrant ratio between VLCCs and LCCs as well as AA/DHA ratio in vitro F508del-CFTR expressing cell lines and in vivo (LAU-7b formulation) in mouse models of CF (Lachance et al., 2013; Garić et al., 2020a; Veltman et al., 2021).