A deeper understanding of how the non-coding RNAs and DNA-methylation stimulates the RAAS, AGT, and ACE genes of the renal system leading to the development of hypertension, would be a step closer to better understanding the actual mechanism by which melatonin works to alleviate hypertension, making it easier to design and develop melatonin-based therapies. Here, ACE is linked to hypertensive disorder.