Another meta-analysis suggested that high or positive expression of PD-L1 in head and neck squamous cell carcinoma (HNSCC) has a good predictive effect for OS at 6 and 12 months [relative risk (RR), 1.30; 95% CI, 1.02 to 1.65; p = 0.03; RR, 1.31; 95% CI, 1.05 to 1.62; p = 0.01] (Huang et al., 2021). The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.