FCGR3A and cancer: Activation of FcγRIIIa on NK cells plays a key role in mediating antibody-dependent cell-mediated cytotoxicity (ADCC), while activation of FcγRIIIa on macrophages is important in mediating antibody-dependent cellular phagocytosis (ADCP) (Morvan and Lanier, 2016), which are the innate immune mechanism that eliminates cancer cells.