In animal models of glaucoma, disrupted BDNF axonal transport was observed, and BDNF injection into the superior colliculus (SC) of neonatal hamsters resulted in a 13–15-fold reduction in RGC pyknosis, showing that the BDNF plays a significant role in promoting the RGC survival (Ma et al., 1998). The gene discussed is BDNF; the disease is glaucoma.