FOLH1 and inflammatory bowel disease: More recently the Slusher team identified that GCPII enzymatic activity is highly upregulated in patient biopsies with inflammatory bowel disease (IBD) and inhibition of this upregulated activity provides therapeutic benefit in preclinical IBD models (Rais et al., 2016; Date et al., 2017; Peters et al., 2019; Peters et al., 2022).