POMC and neoplasm: The α-defensins have therein been reported to be involved in various non-immune physiological processes such as wound healing and promoting collagen expression [21–23], activation of the Nuclear Factor Kappa B (NF-κB) pathway [20], anti-angiogenic, anti-tumor as well as activation of cancerous cell proliferation [24–28], anti-Adrenocorticotropic hormone (ACTH) activity and inhibiting glucocorticoid hormone secretion [9].