We successfully transfected mimic NC, miR-590-5p mimics, vector NC, vector circ-GTF2I, circ-GTF2I + miR-NC, and circ-GTF2I + miR-590-5p into the hypoxia/reoxygenation treatment model to further study the mechanism of miR-590-5p in MI. The gene discussed is GTF2I; the disease is myocardial infarction.