The overexpression of miR-590-5p could effectively inhibit the transcription level of circ-GTF2I and reduce the expression of Bax and Cyt-c, inhibit cardiomyocyte apoptosis, alleviate MIRI and myocardial infarction, improve left cardiac function, and participate in myocardial protection. The gene discussed is BAX; the disease is myocardial infarction.