RARG and acne: Galderma Research and Development LLC has developed trifarotene (Aklief®), a first-in-class selective retinoic acid receptor (RAR)-γ agonist employed to treat acne vulgaris on the trunk and face, as well as lamellar ichthyosis, under license from Mayne Pharma International Ltd. It is a fourth-generation synthetic retinoid and is effective in treating acne's primary pathogenic proceedings.