Compared with participants who did not develop nephropathy, those who developed nephropathy were more likely to be men, belonged to the standard glycemia treatment arm, have a longer duration of diabetes, higher levels of BMI, HbA1c, SBP, triglyceride, RC, eGFR, but had lower levels of HDL, use antihypertensives, were less likely to have CVD, and were less likely to use fibrate and insulin. This evidence concerns the gene INS and diabetes mellitus.