The P2X7 receptor (P2X7R), which primarily acts via NLRP3 inflammasome‐mediated signaling, has been shown to be critical for bacterial killing in monocytes and macrophages (Csoka et al., 2015; Hill et al., 2010), but the role of P2X7R on the endothelium during sepsis has not been well characterized. Here, P2RX7 is linked to Sepsis.