IGF1R and small cell lung carcinoma: Next, we examined the miR-377-3p/miR-494-3p and IGF1R expression in SCLC clinical samples and found that miR-377-3p/miR-494-3p were both down-regulated in SCLC compared to paraSCLC, whereas the IGF1R mRNA showed the opposite trend (Fig. 5D, E).