First, we showed that the miR-377-3p or miR-494-3p inhibitors could rescue the decrease in the mRNA and protein levels of IGF1R and its downstream targets, phosphorylated AKT (p-AKT) and phosphorylated S6 ribosomal protein (p-S6RP) expression upon circVAPA silencing in SCLC cells (Fig. 5F, H and Fig. 6A). This evidence concerns the gene RPS6 and small cell lung carcinoma.