Our main findings are: (i) CF carriers are overrepresented in this cohort, supporting the role of CFTR hypofunction in the predisposition of some patients with asthma to recurrent respiratory infections, (ii) the dominant inflammatory type in these patients is neutrophilic bronchitis, but some have eosinophilic inflammation as well, and (iii) hypertonic saline appears to be effective and is well tolerated in this asthmatic population. Here, CFTR is linked to respiratory tract infectious disorder.