UBE2O promotes the proliferation, epithelial-mesenchymal transformation, and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1 positive feedback loop [19], and UBE2O facilitates tumorigenesis and radioresistance by promoting Mxi1 ubiquitination and degradation [20]. The gene discussed is UBE2O; the disease is breast cancer.