ANO1 and cancer: Moreover, because HPV E7-, but not E6-transfected cancer cells led to hypermethylation of a positively correlated CpG island without a change in TMEM16A expression, they concluded that this hypermethylation caused only by E7 was not sufficient to increase TMEM16A mRNA levels that showed the clinical relevance of both negatively and positively correlated CpG expression levels [142].