EGFR and ovarian carcinoma: Knockdown of TMEM16A contributes to a reduction in AKT, ERK1/2, and v-Src sarcoma viral oncogene homologue (SRC) phosphorylation levels due to decreased autocrine EGFR ligand secretion, reduced EGFR signaling, and decreased cell viability in breast [38] and ovarian cancer cells [148].