This effect is similar to the anti-inflammatory effect of SR9009 on colitis [48], hepatitis [53], pneumonia [54] and other inflammatory diseases [55], which further supports that the NLRP3 inflammasome is under the control of circadian rhythm, and Rev-erbα may play an anti-inflammatory and neuroprotective role by regulating the NLRP3 inflammasome in PD. Here, NLRP3 is linked to hepatitis A virus infection.