Based on previous in vitro findings and PLA study in human tumor sections that CDDP promotes the interaction of Phb1 and p-p53 (ser15) in mitochondria (Figs. 5, 6), we further examined whether stronger mitochondrial Phb1-p-p53 (ser15) interaction is also associated with better prognosis and chemo-responsiveness of OVCA patients. The gene discussed is PHB1; the disease is neoplasm.