For example, the porin B protein of N. meningitides can cause the formation and stimulation of the TLR2/TLR2 homodimers on the CNS cells, thereby initiating downstream pathways resulting in the activation of NF-kB transcription factor and secretion of proinflammatory cytokines, leading to meningitis [42]. This evidence concerns the gene TLR2 and meningitis.