CX3CR1CreERIL-10 knockout mice exhibited depression- and anxiety-like behaviors, along with decreased NR2B (N-methyl-D-aspartate receptor (NMDAR) subunit) and synaptophysin (SYP) levels in the mPFC, and increased NR2B and postsynaptic densitin-95 (PSD95) levels in the amygdala [113]. Here, GRIN2B is linked to major depressive disorder.