Some scholars have manifested that DLX6 is mainly regulated by a new type of upstream transcribed non-coding RNA (EVF-1) and p63 and the abnormal expression of this gene may be related to the occurrence of Split Hand-Foot Malformation (SHFM) and estrogenic Ectodactyly-Ectodermal dysplasia-Cleft lip (EEC) [20, 21]. The gene discussed is DLX6; the disease is exstrophy-epispadias complex.