In the derivation set, twenty-two variables, including age, sex, HBsAg, hepatitis C, cirrhosis, tumor number, largest nodule diameter, capsule, APRI, FIB-4, NLR, WBC, haemoglobin, platelet count, MPV, PDW, AST, ALT, γ-GGT, total bilirubin, AFP, and CA19-9 entered into the original model. This evidence concerns the gene AFP and hepatitis C virus infection.