In the derivation cohort, statistical significance was observed in age, sex, HBsAg, hepatitis C, cirrhosis, tumor number, capsule, the largest nodule diameter, APRI, FIB-4, NLR, WBC, haemoglobin, platelet count, MPV, PDW, AST, ALT, γ-GGT, total bilirubin, AFP, and CA19-9 levels between the two groups (Table 2). The gene discussed is AFP; the disease is Cirrhosis.