These variables are high Khorana scores [14, 15, 17], ECOG of < 2 [14], HBP [15], age < 65 years [16] PDL1 > 1% [16], treatment with a combination of two immunotherapy agents [17], history of coronary artery disease [17], anticoagulant therapy at the start of ICI [17] and being female [18]. Here, CD274 is linked to coronary artery disorder.