For instance, we observed significantly stronger enrichment of TBX21 (adjusted P = 1 × 10−224), RUNX3 (adjusted P = 1 × 10−199), TCF7L2 (adjusted P = 1 × 10−167) and ZEB1 (adjusted P = 1 × 10−118) motifs in severe COVID-19 risk variant-depleted cells. This evidence concerns the gene TCF7L2 and COVID-19.