Median OS and PFS were 17.6 and 6.3 months in the Japanese population and 12.4 and 6.3 months in the total population; the higher percentage of patients with ESCC and ﻿PD-L1 CPS ≥ 10 receiving subsequent systemic therapy in the Japanese population may explain this result. The gene discussed is CD274; the disease is esophageal squamous cell carcinoma.