By contrast, CD8+ T cells with epigenetic landscapes similar to those from normal tumor-adjacent kidney tissue were characterized by binding motif enrichment for KLF2, a transcription factor involved in T cell quiescence38, and several less-described TFs including NFYA, SP4 and PBX3 (Fig. 1c and Extended Data Fig. 3b). This evidence concerns the gene SP4 and neoplasm.