For example, C3_RNAseq, representing naive CD4+ T cells, was characterized by high expression of TCF7 and LEF1 and was almost exclusively populated with cells from blood, whereas cells in the effector T cell clusters C6_CD8_RNAseq and C7,8_CD8_RNAseq expressed high levels of GNLY and originated mainly from tumor or normal adjacent kidney tissue and blood, respectively (Fig. 3b and Extended Data Fig. 6b,c). The gene discussed is LEF1; the disease is neoplasm.