Tumor-infiltrating CD4+ T cells (C12_CD4) were associated with binding motif enrichment for cluster-specific TFs such as members of the POU domain family (POU2F1, POU2F2 and POU2F3) (Extended Data Fig. 3b), in addition to TF programs shared with dysfunctional CD8+ T cells (Fig. 1f). This evidence concerns the gene POU2F1 and neoplasm.