CD4 and neoplasm: For example, C3_RNAseq, representing naive CD4+ T cells, was characterized by high expression of TCF7 and LEF1 and was almost exclusively populated with cells from blood, whereas cells in the effector T cell clusters C6_CD8_RNAseq and C7,8_CD8_RNAseq expressed high levels of GNLY and originated mainly from tumor or normal adjacent kidney tissue and blood, respectively (Fig. 3b and Extended Data Fig. 6b,c).